Are you interested in one of our studies?
Contact Anesthesiology Research at research@anesthesia.wisc.edu and we will put you in contact with our research staff.
Dr. Alaa Abd-Elsayed
Product Surveillance Registry (PSR)
Site Investigator: Dr. Alaa Abd-Elsayed
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products. The Registry data is intended to benefit and support interests of patients, hospitals, clinicians, regulatory bodies, payers, and industry by streamlining the clinical surveillance process and facilitating leading edge performance assessment via the least burdensome approach.
Observational, Post Market Study in Treating Chronic Upper Extremity Limb Pain (Procura)
Site Investigator: Dr. Alaa Abd-Elsayed
This is a post-market, open-label, prospective, multi-center, observational study evaluating upper limb pain relief with the DTM™ SCS programming approach.
SCS Programming Study in Treating Intractable Chronic Back Pain (NOVA)
Site Investigator: Dr. Alaa Abd-Elsayed
This is an open-label prospective, randomized, controlled, multi-center study comparing DTM-SCS programming approach to Conventional SCS programming approach.
The purpose of this investigational study is to study the effects of Differential Target Multiplexed Spinal Cord Stimulation (DTM-SCS) in subjects with chronic, intractable pain of the trunk with or without lower limb pain, including unilateral or bilateral pain without prior history of spine surgery and refractory to conservative and surgical interventions.
Dr. Guelay Bilen-Rosas
Ultrasound Study in Sedated Patients
Principal Investigator: Dr. Guelay Bilen-Rosas
The Bilen-Rosas Laboratory explores non-invasive methods of quantifying airflow using ultrasound signaling. Our mission and passion is to prevent catastrophic outcomes by developing a clinically useful respiratory monitoring device.
Monitoring respiratory parameters and recognizing abnormal values is vital for the safety of patients under sedation. When respiratory compromise is not detected in time, a lack of oxygenation to the brain and heart leads to grave consequences including permanent neurologic and cardiac damage or even death. Advanced detection can save lives and reduce costs.
Our lab is developing a patented methodology that uses ultrasound signaling at the air–tissue interface to quantify and correlate airflow and flow parameter changes in the expiratory and inspiratory phases of respiration. With machine learning methods, this technology estimates real-time, continuous and quantitative feedback of respiratory parameters including airflow velocities, respiratory rate, tidal volume, phases of breathing and apnea/obstructive events.
The overall objective of our research is to develop a miniaturized, wearable respiratory monitor that uses ultrasound signaling to continuously and quantitatively monitor respiration.
Dr. Molly Groose
Parenteral Ascorbic Acid Repletion in Transplantation (PARTI): A Randomized, Double-Blinded, Placebo-Controlled Trial
Principal Investigator: Dr. Molly Groose
This study aims to determine how well ascorbic acid (Vitamin C) improves organ function and blood flow following liver transplantation compared to a placebo. Liver transplantation improves survival and reduces the burden of symptoms. The large changes in blood pressure and blood flow during liver transplants can cause major inflammation. With the significant morbidity and mortality associated with the operation and recipient need so far in excess of available donors, improving recipient outcomes and maximizing graft survival is critically important. Vitamin C improves outcomes in patients on life-support due to infections, traumatic injuries or burns, and it may improve blood pressure and prevent injury to organs. This research will help us understand if Vitamin C improves outcomes in liver transplant patients.
Dr. William Hartman
A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age
Principal Investigator: Dr. William Hartman
The primary purpose of this phase 2/3 study, nicknamed the KidCOVE Study, is to test the safety and effectiveness of the study vaccine, called mRNA-1273, that may protect children between the ages of 6 months to <12 years from getting sick if they come into contact with SARS-CoV-2, which causes COVID-19. Moderna will be recruiting multiple age groups from 6 months to <12 years and staggering the recruitment of each group. The goal of this study is to evaluate the safety and effectiveness of different dose amounts and regimens, including a three-dose regimen in healthy children.
Phase 3 Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults
Principal Investigator: Dr. William Hartman
The aim of this phase III randomized, double-blind, placebo-controlled multicenter study is to assess the safety, efficacy, and immunogenicity of AZD1222, a non-replicating ChAdOx1 vector vaccine, for the prevention of COVID-19. The COVID-19 pandemic has caused major disruption to healthcare systems with significant socioeconomic impacts. Currently, there are no specific treatments available against COVID-19 and accelerated vaccine development is urgently needed. A safe and effective vaccine for COVID-19 prevention would have significant public health impact.
Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19
Principal Investigator: Dr. William Hartman
This expanded access program will provide access to investigational convalescent plasma for patients in acute care facilities infected with SARS-CoV-2 who have severe or life-threatening COVID-19, or who are judged by a healthcare provider to be at high risk of progression to severe or life-threatening disease.
Dr. Jared Hylton
Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?
Site Investigator: Dr. Jared Hylton
This is a prospective randomized multi-center non-inferiority trial conducted through the Pediatric Regional Anesthesia Network study sites to determine if caudal block increases the incidence of urethrocutaneous fistula following distal or mid shaft hypospadias repair compared with penile nerve block.
Dr. Richard Lennertz
Regional Versus General Anesthesia for Promoting Independence After Hip Fracture (REGAIN)
Principal Investigator: Dr. Richard Lennertz
The purpose of this pragmatic multicenter prospective randomized trial of spinal versus general anesthesia for hip fracture surgery is to evaluate the association of anesthesia technique with functional recovery after hip fracture.
Dr. Patrick Meyer
Dr. Eric Simon
Pecto-Intercostal Fascial Plane Block for Enhanced Recovery After Cardiac Surgery
Principal Investigators: Dr. Patrick Meyer and Dr. Eric Simon
This prospective, double-blind, randomized controlled trial will evaluate whether bilateral pecto-intercostal fascial plane blocks (PIFB) with liposomal and standard bupivacaine reduce pain and opioid needs in patients undergoing cardiac surgery by median sternotomy compared to controls (sham blocks with saline). The primary hypothesis is that total daily opioid consumption in the 72 hours after surgery will be reduced by 25% for patients who receive effective regional anesthesia with liposomal bupivacaine via PIFB compared to patients who receive standard of care without effective regional anesthesia (saline only via PIFB).
Dr. Robert Pearce
Interventions for POstoperative Delirium-Biomarker-3 (IPOD-B3)
Principal Investigator: Dr. Robert Pearce
ClinicalTrials.gov Study Page
Based on prior models and prior cognitive theories, our Cognitive Disintegration model suggests a critical role of neural network connectivity in the predisposition to, and pathogenesis of, delirium. The neurophysiological hallmark of delirium is increased slow wave activity (SWA) on the electroencephalogram (EEG). We propose that delirium occurs as neural networks “disintegrate” through acute increases in SWA and investigating the underlying mechanisms may yield novel therapeutics for delirium. We are conducting a perioperative cohort study employing preoperative magnetic resonance imaging (MRI) and high-density EEG to probe changes in network connectivity and SWA and correlate these changes with changes in inflammation and cognition.
Interventions for POstoperative Delirium: Biomarker-PET 2 (IPOD-PET2)
Principal Investigator: Dr. Robert Pearce
This study focuses on the overlapping pathology of dementia and delirium. The inter-relationship between dementia and delirium is poorly understood with each condition predisposing to the other. This study (nested within IPOD-B3) will investigate associations with postoperative delirium (in the immediate postoperative period) and PET-amyloid levels detected.